MicroRNAs in Animal Models of HCC
Identifieur interne : 000630 ( Main/Exploration ); précédent : 000629; suivant : 000631MicroRNAs in Animal Models of HCC
Auteurs : Francesca Fornari [Italie] ; Laura Gramantieri ; Elisa Callegari ; Ram C. Shankaraiah ; Fabio Piscaglia [Italie] ; Massimo Negrini ; Catia Giovannini [Italie]Source :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Molecular heterogeneity and absence of biomarkers for patient allocation to the best therapeutic option contribute to poor prognosis of advanced stages. Aberrant microRNA (miRNA) expression is associated with HCC development and progression and influences drug resistance. Therefore, miRNAs have been assayed as putative biomarkers and therapeutic targets. miRNA-based therapeutic approaches demonstrated safety profiles and antitumor efficacy in HCC animal models; nevertheless, caution should be used when transferring preclinical findings to the clinics, due to possible molecular inconsistency between animal models and the heterogeneous pattern of the human disease. In this context, models with defined genetic and molecular backgrounds might help to identify novel therapeutic options for specific HCC subgroups. In this review, we describe rodent models of HCC, emphasizing their representativeness with the human pathology and their usefulness as preclinical tools for assessing miRNA-based therapeutic strategies.
Url:
DOI: 10.3390/cancers11121906
PubMed: 31805631
PubMed Central: 6966618
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MicroRNAs in Animal Models of HCC</title><author><name sortKey="Fornari, Francesca" sort="Fornari, Francesca" uniqKey="Fornari F" first="Francesca" last="Fornari">Francesca Fornari</name><affiliation><nlm:aff id="af1-cancers-11-01906">Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy;<email>fabio.piscaglia@unibo.it</email> (F.P.);<email>catia.giovannini4@unibo.it</email> (C.G.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01906">Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna</wicri:regionArea><wicri:noRegion>40138 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Gramantieri, Laura" sort="Gramantieri, Laura" uniqKey="Gramantieri L" first="Laura" last="Gramantieri">Laura Gramantieri</name><affiliation><nlm:aff id="af1-cancers-11-01906">Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy;<email>fabio.piscaglia@unibo.it</email> (F.P.);<email>catia.giovannini4@unibo.it</email> (C.G.)</nlm:aff></affiliation></author><author><name sortKey="Callegari, Elisa" sort="Callegari, Elisa" uniqKey="Callegari E" first="Elisa" last="Callegari">Elisa Callegari</name><affiliation><nlm:aff id="af3-cancers-11-01906">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Bologna, Italy;<email>elisa.callegari@unife.it</email> (E.C.);<email>shnrch@unife.it</email> (R.C.S.);</nlm:aff></affiliation></author><author><name sortKey="Shankaraiah, Ram C" sort="Shankaraiah, Ram C" uniqKey="Shankaraiah R" first="Ram C." last="Shankaraiah">Ram C. Shankaraiah</name><affiliation><nlm:aff id="af3-cancers-11-01906">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Bologna, Italy;<email>elisa.callegari@unife.it</email> (E.C.);<email>shnrch@unife.it</email> (R.C.S.);</nlm:aff></affiliation></author><author><name sortKey="Piscaglia, Fabio" sort="Piscaglia, Fabio" uniqKey="Piscaglia F" first="Fabio" last="Piscaglia">Fabio Piscaglia</name><affiliation><nlm:aff id="af1-cancers-11-01906">Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy;<email>fabio.piscaglia@unibo.it</email> (F.P.);<email>catia.giovannini4@unibo.it</email> (C.G.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01906">Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna</wicri:regionArea><wicri:noRegion>40138 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Negrini, Massimo" sort="Negrini, Massimo" uniqKey="Negrini M" first="Massimo" last="Negrini">Massimo Negrini</name><affiliation><nlm:aff id="af3-cancers-11-01906">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Bologna, Italy;<email>elisa.callegari@unife.it</email> (E.C.);<email>shnrch@unife.it</email> (R.C.S.);</nlm:aff></affiliation></author><author><name sortKey="Giovannini, Catia" sort="Giovannini, Catia" uniqKey="Giovannini C" first="Catia" last="Giovannini">Catia Giovannini</name><affiliation><nlm:aff id="af1-cancers-11-01906">Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy;<email>fabio.piscaglia@unibo.it</email> (F.P.);<email>catia.giovannini4@unibo.it</email> (C.G.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01906">Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna</wicri:regionArea><wicri:noRegion>40138 Bologna</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31805631</idno><idno type="pmc">6966618</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966618</idno><idno type="RBID">PMC:6966618</idno><idno type="doi">10.3390/cancers11121906</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000908</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000908</idno><idno type="wicri:Area/Pmc/Curation">000908</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000908</idno><idno type="wicri:Area/Pmc/Checkpoint">000580</idno><idno type="wicri:explorRef" 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and Surgical Sciences, University of Bologna, 40138 Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna</wicri:regionArea><wicri:noRegion>40138 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Gramantieri, Laura" sort="Gramantieri, Laura" uniqKey="Gramantieri L" first="Laura" last="Gramantieri">Laura Gramantieri</name><affiliation><nlm:aff id="af1-cancers-11-01906">Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy;<email>fabio.piscaglia@unibo.it</email> (F.P.);<email>catia.giovannini4@unibo.it</email> (C.G.)</nlm:aff></affiliation></author><author><name sortKey="Callegari, Elisa" sort="Callegari, Elisa" uniqKey="Callegari E" first="Elisa" last="Callegari">Elisa Callegari</name><affiliation><nlm:aff id="af3-cancers-11-01906">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Bologna, Italy;<email>elisa.callegari@unife.it</email> (E.C.);<email>shnrch@unife.it</email> (R.C.S.);</nlm:aff></affiliation></author><author><name sortKey="Shankaraiah, Ram C" sort="Shankaraiah, Ram C" uniqKey="Shankaraiah R" first="Ram C." last="Shankaraiah">Ram C. Shankaraiah</name><affiliation><nlm:aff id="af3-cancers-11-01906">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Bologna, Italy;<email>elisa.callegari@unife.it</email> (E.C.);<email>shnrch@unife.it</email> (R.C.S.);</nlm:aff></affiliation></author><author><name sortKey="Piscaglia, Fabio" sort="Piscaglia, Fabio" uniqKey="Piscaglia F" first="Fabio" last="Piscaglia">Fabio Piscaglia</name><affiliation><nlm:aff id="af1-cancers-11-01906">Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy;<email>fabio.piscaglia@unibo.it</email> (F.P.);<email>catia.giovannini4@unibo.it</email> (C.G.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01906">Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna</wicri:regionArea><wicri:noRegion>40138 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Negrini, Massimo" sort="Negrini, Massimo" uniqKey="Negrini M" first="Massimo" last="Negrini">Massimo Negrini</name><affiliation><nlm:aff id="af3-cancers-11-01906">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Bologna, Italy;<email>elisa.callegari@unife.it</email> (E.C.);<email>shnrch@unife.it</email> (R.C.S.);</nlm:aff></affiliation></author><author><name sortKey="Giovannini, Catia" sort="Giovannini, Catia" uniqKey="Giovannini C" first="Catia" last="Giovannini">Catia Giovannini</name><affiliation><nlm:aff id="af1-cancers-11-01906">Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy;<email>fabio.piscaglia@unibo.it</email> (F.P.);<email>catia.giovannini4@unibo.it</email> (C.G.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01906">Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna</wicri:regionArea><wicri:noRegion>40138 Bologna</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancers</title><idno type="eISSN">2072-6694</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Molecular heterogeneity and absence of biomarkers for patient allocation to the best therapeutic option contribute to poor prognosis of advanced stages. Aberrant microRNA (miRNA) expression is associated with HCC development and progression and influences drug resistance. Therefore, miRNAs have been assayed as putative biomarkers and therapeutic targets. miRNA-based therapeutic approaches demonstrated safety profiles and antitumor efficacy in HCC animal models; nevertheless, caution should be used when transferring preclinical findings to the clinics, due to possible molecular inconsistency between animal models and the heterogeneous pattern of the human disease. In this context, models with defined genetic and molecular backgrounds might help to identify novel therapeutic options for specific HCC subgroups. In this review, we describe rodent models of HCC, emphasizing their representativeness with the human pathology and their usefulness as preclinical tools for assessing miRNA-based therapeutic strategies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Liu, C G" uniqKey="Liu C">C.G. Liu</name></author><author><name sortKey="Calin, G A" uniqKey="Calin G">G.A. Calin</name></author><author><name sortKey="Meloon, B" uniqKey="Meloon B">B. Meloon</name></author><author><name sortKey="Gamliel, N" uniqKey="Gamliel N">N. Gamliel</name></author><author><name sortKey="Sevignani, C" uniqKey="Sevignani C">C. Sevignani</name></author><author><name sortKey="Ferracin, M" uniqKey="Ferracin M">M. Ferracin</name></author><author><name sortKey="Dumitru, C D" uniqKey="Dumitru C">C.D. Dumitru</name></author><author><name sortKey="Shimizu, M" uniqKey="Shimizu M">M. Shimizu</name></author><author><name sortKey="Zupo, S" uniqKey="Zupo S">S. 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Shankaraiah</name></noCountry><country name="Italie"><noRegion><name sortKey="Fornari, Francesca" sort="Fornari, Francesca" uniqKey="Fornari F" first="Francesca" last="Fornari">Francesca Fornari</name></noRegion><name sortKey="Giovannini, Catia" sort="Giovannini, Catia" uniqKey="Giovannini C" first="Catia" last="Giovannini">Catia Giovannini</name><name sortKey="Piscaglia, Fabio" sort="Piscaglia, Fabio" uniqKey="Piscaglia F" first="Fabio" last="Piscaglia">Fabio Piscaglia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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